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NP and annulus fibrosus (AF) cells, along with macrophages, T cells, and neutrophils, secrete high levels of pro-inflammatory cytokines such as tumour necrosis factor (TNF)-α, interferon-γ (IFN-γ), IL-1β, IL-10, IL-4, IL-6, IL-17, IL-2, IL-8, and chemokines like CCR6 and CCL20

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However, cardiac arrest was observed in 10% (3 out of 30) of patients with advanced solid tumors receiving a dose of 12 mg/kg in a dose-escalation trial of Sym004 (a 1:1 mixture of cetuximab and panitumumab), which was regarded as an incidental finding [280]

though results will vary based on individual commitment to exercise and diet.