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This approach, combined with the potential of combination therapies involving CDK and HSP-90 inhibitors, could significantly impact cancer progression and drug resistance by stabilizing HIF1α, suggesting a synergistic mechanism that broadens the scope of combating therapy resistance (1, 75)

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10.1056/NEJMra1510062 [DOI] [PubMed] [Google Scholar] Wu L, Sedgwick AC, Sun X, Bull SD, He XP, James TD (2019) Reaction-based fluorescent probes for the detection and imaging of reactive oxygen, nitrogen, and sulfur species