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FIGURE 3 2.4 Inflammation response Chronic inflammation in the kidney has been recognized as a key pathological mechanism in the development of DKD, and the inflammatory response plays an integral role in the formation and progression of renal fibrosis (RF) ( Research has demonstrated that interleukins such as Interleukin 1 (IL-1), IL-6, and interleukin 18 (IL-18) manifest substantial expression alterations in renal tissues of DKD patients, exhibiting a close correlation with renal disease