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In particular, NQO1 is a detoxificant enzyme that protects cells from oxidative stress by lowering ROS, protecting DNA, proteins and lipids from hyperoxia-mediated damage ( Figure 3 Most of these antioxidant enzymes not only eliminate the free radicals produced by viral infection, but also contribute to decrease cytokine-mediated inflammation through the induction of leukotriene B4 reductase, a NAD(P)H-dependent oxidoreductase which inactivates leukotriene B4 involved in the inflammation and reduces oxidative stress counteracting the iron overload by increasing the ferritin levels (Dick et al., 2001)

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Antunes, F., Cadenas, E