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During the GGCX-mediated reaction, VKH 2 is oxidized to vitamin K epoxide, and then converted to vitamin K quinone by vitamin K epoxide reductase (VKOR), whose activity is inhibited by warfarin

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Vitamin B12 deficiency could occur despite the normal plasma concentrations of vitamin B12 and measurement of plasma concentrations of the metabolic marker, MMA, in this target group could be important to detect intracellular B12 deficiency