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The reason may be the negative feedback between the 3-MST and the CBS/CSE system of H 2 S, which may also be why CSE/H 2 S promotes HCC, while 3-MST/H 2 S has the opposite effect

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In fact, the main disadvantage of 2-VP is that its reaction with GSH is very slow (about 500-fold slower than that of NEM) and it does not permeate cell membranes [12,13]