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and a 16- week randomized clinical trial) and in HIV-patients (a 20- week open label trial published Sept 2020) showed that compared to young controls (for elderly human trials) and non-HIV controls (for the HIV clinical trial), elderly humans and HIV patients had severely elevated inflammation (plasma IL-6, CRP and TNF-alpha), endothelial dysfunction (plasma sICAMl, sVCAMl and E- selectin), insulin resistance, genomic damage, impaired autophagy, mitophagy and mitochondrial function and energy regulation, and with muscle weakness, poor exercise capacity and cognitive impairment

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After 72 h incubation with the antibody-drug conjugates, the vitality was determined in these cells with the Cell Titer Glow Luminescent Cell Viability Assay as described above