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demonstrated the down-regulation of SOX2, a stemness-associated gene, and resultant decrease of mass forming liver cancer stem cells ( in-vitro studies have not been conducted in colorectal cancer, however the underlying mechanism of Wnt/β-catenin signaling contributing to radiotherapy resistance in colorectal cancer has been explored, and dysregulated Notch or Wnt/β-catenin signaling has been demonstrated ( 6.3.2 JAK/STAT pathway While the Wnt/β-catenin pathway has been explored significantly, there are other contributing signaling pathways to therapeutic resistance that are explored in the literature