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Compared with that in healthy mice, prolonged activation of mTORC1 signaling in CD4 + T cells leads to increased expression of the transcription factor HIF-1α, an essential mediator that dramatically increases the expression of enzymes related to the glycolysis pathway, in EAE mice [32]

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1 Introduction AML is a highly aggressive hematologic malignancy characterized by substantial biological heterogeneity, driven by the clonal expansion of hematopoietic stem and progenitor cells