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The four ways of initiating ferroptosis are currently discussed [151]: Class I ferroptosis inducers work via the inhibition of cystine import by system xc- and driving depletion of GSH, class II ferroptosis inducers act by directly targeting and inactivating GPx4, class III ferroptosis inducers cause depletion of GPx4 and CoQ10 generated via the squalene synthase (SQS)–mevalonate pathway, and class IV ferroptosis inducers increase the cytosolic labile iron pool (LIP) or oxidize iron to induce lipid peroxidation [152]

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Blockade of insulin-like growth factor-I has complex effects on structural plasticity in the hippocampus