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Triazolopyrimidines and Pyrazolo[3,4-d]pyrimidines Triazolopyrimidines and pyrazolo[3,4-d]pyrimidines are frequently used heterocyclic cores in kinase inhibitor chemistry because they are purine bioisosteres and can mimic the binding mode of the ATP adenine moiety within the catalytic cleft, forming characteristic hydrogen bonds with residues in the hinge region [67,68,69]
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