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4.4.2 Adsorptive-mediated transcytosis (AMT) Unlike RMT, Adsorptive-mediated transcytosis (AMT) does not rely on specific ligand-receptor interactions but instead exploits the net surface charge of therapeutic agents or delivery systems to promote nonspecific adsorption, endocytosis, and subsequent vesicular transport across the BBB (Herve et al., 2008
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