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ATPase Inhibitory Factor 1 (IF1) is a low molecular weight (~10 kDa) mitochondrial protein which acts as a natural inhibitor of ATP synthase, but does not interfere with its coupling activity (Cabezon et al., In the heart, the α subunit of ATP synthase is glutathionylated during dyssynchronous heart failure (DHF) and this can be induced by GSSG in a dose-dependent manner
the body begins to produce less and less Glutathione itself so supplementation can be very beneficial in keeping levels up