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Key questions remain regarding its ability to effectively inhibit NLRP3 inflammasome activation within the complex milieu of diabetic lung injury, and whether long-term suppression of this core innate immune pathway might lead to the activation of compensatory inflammatory pathways or other unknown off-target effects, all of which require longer-term clinical investigation
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When a target molecule is known, elucidation of the biosynthetic enzymes starts with a chemically reasonable biosynthetic hypothesis of the pathway
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