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For example, inhaled exosomes or lipid nanoparticles (LNPs) can be engineered to carry ferroptosis inhibitors (e.g., Liproxstatin-1) or therapeutic nucleic acids (e.g., siRNA targeting ACSL4 or overexpressing GPX4 mRNA)

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Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice