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LYC inhibits EGF-induced JAK/STAT signaling as well as various downstream STAT3 targets, such as cyclin D1, Bcl-2, Bcl-xL, matrix metalloproteinase 2 (MMP2), and the EMT promoter Twist, which lowers prostate cancer cell line proliferation, migration, invasion (Sancha et al., 2023)

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Testosterone levels drop with many common medications, whether by design or as a side effect