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Vitamin B12 and bone density in osteoporotic patients: A clinical trial

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Key Takeaways Functional vitamin B12 deficiency affects roughly 33% of Crohn's disease patients, compared with 16% of those with ulcerative colitis (1) Standard serum B12 tests detected deficiency in only 5% of Crohn's patients, while more sensitive holoTC and MMA testing identified it in 32% (1) Ileal resections greater than 20 cm carry a 6.7 times higher odds of B12 deficiency (1) Oral cyanocobalamin at 1 mg/day normalized B12 levels in 94.7% of deficient Crohn's patients in a clinical study (4) Symptoms like fatigue, numbness, and brain fog are often dismissed as part of Crohn's itself, delaying proper treatment Regular monitoring with functional tests is essential, especially after ileal surgery Why Crohn's Disease Puts You at Risk for Vitamin B12 Deficiency Vitamin B12, also known as cobalamin, depends on a very specific stretch of intestine for absorption - and it is the same stretch that Crohn's disease targets most often