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Determinants of outcome: “where, when, how much” Outcome is governed by three non-independent axes—where, when and how much: where the ROS originate and in which compartment (e.g., NOX microdomains versus mitochondria and ER versus peroxisome) sets the immediate molecular targets and the surrounding antioxidant context that shapes reactivity (To et al

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Although conditioned media from senescent fibroblasts can drive fibrosis in bystander cells, conditioned media from senescent bronchiolar epithelial cells fails to invoke a fibrotic response, suggesting that senescence and SASP is heterogeneous