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Research has shown that curcumin can inhibit TLR4/NF-κB, MAPK, and NLRP3 inflammasome, suppress IKKβ activity, downregulate miR-155, reduce M1 markers such as iNOS and COX-2, and simultaneously activate Nrf2 to inhibit ROS accumulation, induce M2 phenotype polarization, exert anti-inflammatory and antioxidant activities, and effectively alleviate synovial inflammation and cartilage and bone destruction in RA (Mohammadian Haftcheshmeh and Momtazi-Borojeni, 2020

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