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Considering the close phylogenetic similarity between ALK7 and the TGFb pathway receptors ALK4 and ALK5 [30,31,32], we hypothesized that ALK4 and ALK5 might be potential off-targets of the ALK7 esiRNA
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A double-blind placebo-controlled phase I trial (123) demonstrated that berberine reduced colonic tissue inflammation (Geboes score) (224) in mesalamine-treated UC patients
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