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Mechanistically, cancer cells capable of inducing cancer cachexia are secreting IL-6, which subsequently induces autophagy in differentiated muscle cells via IL-6 signaling and therefore might be relevant for the characteristic muscle and weight loss during cancer cachexia (276)
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In addition, folate, which acts to increase an enzyme in the salvage pathway for BH4 (more on this below), was also able to help attenuate the aortic valve calcification.[ref] Cardiomyopathy due to tetrahydrobiopterin deficiency: Deficiency of endothelial BH4 in the heart leads to NOS uncoupling and decreased endothelial production of nitric oxide
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