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The Neh2 domain, which contains ETGE and DLG motifs, is pivotal for Keap1 binding and ubiquitination, whereas the Neh1 domain features a basic leucine zipper (bZIP) structure essential for DNA binding and dimerization with small Maf proteins [17]

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Human trials improved memory scores in adults with mild cognitive impairment reduced inflammatory markers associated with neurodegeneration Mechanism suppresses neuroinflammation signals from the gut alters tryptophan metabolism (affecting serotonin pathways) Strength of evidence: Very promising for memory 4