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These variants are generally observed in patients with BCR :: ABL1 -like ALL who have CRLF2 abnormalities, although JAK2 variants are also observed in approximately 25% of children with Down syndrome and ALL, occurring exclusively in cases with CRLF2 gene rearrangements.[5,9-11] Several kinase genes and cytokine receptor genes are activated by translocations, as described below in the discussion of BCR :: ABL1 ALL and BCR :: ABL1 -like ALL
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