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In addition, the HBx protein-mediated activation of Nrf2 has been introduced to trigger the upregulation of glucose-6-phosphate dehydrogenase, thereby reprogramming metabolism of glucose, and may participate in the development of HCC (Liu et al., 2015)
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• Dose- and cell type-dependent research is essential to determine the therapeutic potential of 4-HNE in immune-related diseases
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