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from the digestion tract, to the nucleus tractus solitarius (NTS) in the brain stem from which further projections reach different brain regions including the arcuate nucleus (ARC) and the lateral hypothalamic area (LH) in the hypothalamus
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2J, K), and a 1.6 Å resolution crystal structure revealed this was due to conformational occlusion of the αWD40 binding site by an inward rotation of nearby Arg13 and His31 side chains, rather than loss of Lys15 interactions (Fig