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Multiple sclerosis rates have increased significantly over the past 40 years. Genetics alone do not explain that trajectory. The evidence points to environmental factors, including toxin exposure and chronic infections, interacting
High-sensitivity C-reactive protein (CRP) measurements were done using the ACE High Sensitivity C-Reactive Protein Reagent (ACI-22) for the first batch and the CRP (HS) Wide Range kit (Pointe Scientific) for the second batch on an ACE Clinical Chemistry System (Alfa Wassermann, Inc)
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Thus, it may be possible to selectively tune endogenous T cell responses by appropriate targeting of these co-stimulatory and co-inhibitory pathways