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N-Acetyl-p-benzoquinone imine (NAPQI), the toxic metabolite of APAP, besides its intrinsic ability to form aspecific chemical adducts with proteins, promotes the excessive accumulation of ROS mostly depleting the GSH pool that it is required for its detoxification
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Moreover, β-glucan was tested in human colon cancer cells (SNU-C4) and it exhibited antiproliferation activity by reducing Bcl2 expression and upregulation of BAX and caspase-3 levels (298)
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