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Primary endpoints: tolerability, pharmacokinetics (Cmax, Tmax, AUC, half-life), and target engagement biomarkers (plasma 1-methylnicotinamide as surrogate for NNMT activity, whole-blood NAD+)

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[DOI] [PubMed] [Google Scholar] 14.Almohanna H.M., Ahmed A.A., Tsatalis J.P., Tosti A