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Thus, the immunometabolic landscape of the asthmatic airway directly dictates cellular fate by modulating the core executers of ferroptosis, integrating inflammatory cues with metabolic and iron homeostasis to drive disease progression

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of NO:2) Dose Cmax, Group animals Test Article Dosing Route Level F, (%) (%) 1 3 MEDI7219 (SEQ ID NO: 2) Intravenous 0.05 mg kg 100 - Enterically Coated tablet: 3 mg MEDI7219 (SEQ ID 2 5 NO:2), 100 mg Sodium Oral tablet 3 mg/animal 15.5 86 Chenodeoxycholate, 200 mg Propyl Gallate Enterically Coated tablet: 10 mg MEDI7219 (SEQ ID 3 5 NO:2), 100 mg Sodium Oral tablet 10 mg/animal 7.53 118.9 Chenodeoxycholate, 200 mg Propyl Gallate Enterically Coated tablet: 3 mg MEDI7219 (SEQ ID 4 5 NO:2), 75 mg Sodium Oral tablet 3 mg/animal 7.52 88.8 Chenodeoxycholate, 225 mg Propyl Gallate Enterically Coated tablet: 3 mg MEDI7219 (SEQ ID 5 7 NO:2), 50 mg Sodium Oral tablet 3mg/animal 11.1 100.1 Chenodeoxycholate, 100 mg Propyl Gallate Enterically Coated tablet: 10 mg MEDI7219 (SEQ ID 6 7 NO:2), 50 mg Sodium Oral tablet 10 mg/animal 13.5 94.1 Chenodeoxycholate, 100 mg Propyl Gallate Enterically Coated tablet: 3 mg MEDI7219 (SEQ ID 7 5 NO:2), 150 mg Sodium Oral tablet 3 mg/animal 7.53 80.9 Chenodeoxycholate, 300 mg Propyl Gallate Enterically Coated tablet: 3 mg MEDI7219 (SEQ ID 8 5 NO:2), 150 mg Sodium Oral tablet 3mg/animal 6.62 73.7 Chenodeoxycholate, 150 mg Propyl Gallate Enterically Coated tablet: 1 mg MEDI7219 (SEQ ID 9 5 Oral tablet 1 mg/animal 4.22 14.1 NO:2), 100 mg Sodium Chenodeoxycholate, 200 mg Propyl Gallate 1 mg MEDI7219 (SEQ ID NO:2), 100 mg Sodium 10 5 Oral tablet 1 mg/animal 1.11 94.7 Chenodeoxycholate, 200 mg Propyl Gallate 1 mg MEDI7219 (SEQ ID NO:2), 100 mg Sodium 11 5 Oral tablet 1 mg/animal 4.78 57.6 Chenodeoxycholate, 200 mg Propyl Gallate Example 16 [0333] Ten different Multi-unit particulate (MUPS) formulations were prepared (Table 23) using the MEDI7219 (SEQ ID NO:2) peptide and permeation enhancers