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However, GCL is upregulated by estradiol, leading to a higher concentration of glutamyl-cysteine (Glut-Cys) in females, thereby driving increased GS flux

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Considering the function of GST to catalyze reactions of conjugation of lipid peroxidation products with GSH 62, thereby reducing the toxicity of electrophylic compounds and their reactivity towards nucleophilic groups in biomolecules, it is logical that the activity of the GST measured in incipient cataract is higher (2.46 1.14 U/g protein), because at the beginning of the development of the cataract the most intense is the process of lipid peroxidation