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Also the results of a small number of PD patients treated with tricyclics and SSRIs plus rasagiline in the TEMPO-, PRESTO- and LARGO-studies do not give evidence for the "serotonin-syndrome", the population incidence of serotonin toxicity in those patients has a 9, 5% probability of being less than 1, 2% (Pannisset et al., 2007

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Both presynaptic and postsynaptic MORs and KORs have been shown to regulate hypothalamus neurons