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Oxidative stress is also markedly increased in hypertensive patients with renovascular disease.[22] Furthermore, there is a correlation between renin activation and elevated oxidative stress which may suggest that angiotensin II is a stimulus for oxidant stress in renovascular disease.[23] The role of oxidative stress in hypertension and the possible mechanisms involved are well documented in a couple of recently published original and review papers[9,10] and are further discussed in this paper

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For instance, while damage to OLs results in both demyelination and abnormal myelin formation, ischemic events and traumatic injuries also stimulate OPC proliferation and migration (Zhang et al., 2013