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10.1053/j.ajkd.2014.09.023 26 HuD
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In addition to its role in memory formation, mTOR signaling exerts distinct and reciprocal effects on CD4+ T helper cell differentiation: mTORC1 signaling promotes Th1, Th2, and Th17 differentiation, whereas mTORC2 signaling—defined by the interaction of the core kinase mTOR with Rictor rather than Raptor, the defining subunit of mTORC1—favors Th2 differentiation [20, 33]