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Similar trends were observed for the primary caffeine metabolite, paraxanthine (80% of caffeine is metabolized to paraxanthine), which was higher in older donors or younger females of Caucasian descent, showing a strong positive correlation (Spearman 0.7) and stable ratios across donor ages and sex ( Online Supplementary Figure S1A-C )

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However, other types of inflammation can be more persistent, such as with autoimmune diseases like arthritis, where the immune system acts as if it’s constantly under attack