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Antioxidant supplementation statistically improved IIEF-EF compared to placebo, with a mean difference between groups of 5.5 points (95% CI: 3.7–7.3
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On the other hand, low portal insulin levels (e.g., during prolonged fasting) reduce hepatic GHR expression, thereby reducing IGF-1 levels and increasing GH concentrations by the lack of IGF-1 feedback on pituitary GH secretion (Fig
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