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And finally, increased expression of multidrug resistance transporter proteins in response to oxidative stress increases the export of GSH out of cells, including from endothelial cells of the BBB, further depleting neuronal GSH [55]
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Second, the role of metabolic reprogramming in ferroptosis highlights how sustained mechanical stress and inflammation reshape lipid, amino acid, iron, and glucose metabolic pathways in OA chondrocytes and synovial cells
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