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8 Limitations of the study While this review brings together extensive in vitro and preliminary in vivo evidence on clove-derived phytochemicals, several limitations temper the strength of our conclusions

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Interestingly, both kinase DYRK1A and Akt have convergent effects by directly inactivating GSK3β by phosphorylation at Thr356 (for DYRK1A) (Song et al., 2015) and on serine 9 (for Akt) (Tlili et al., 2013