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This drawback can be due to only one side of the NO-system employed in the studies (i.e., decreased function by L-NAME application) while the other part remained unchecked (i.e., over-increased function by L-arginine, and vice versa) [124,125]
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However, deficiencies caused by impaired absorption, especially due to the lack of intrinsic factors (IFs), can lead to rapid deterioration within two to five years