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Specifically, the imine and allysine intermediates generated by lysyl oxidase activity are labeled directly with biotin-hydrazide (BHZ
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A further possibility is that under normal physiological conditions GSK-3 activity is inhibited to a sufficient extent to cause sub-optimal phosphorylation of the DSGIS-containing phosphodegron in the Neh6 domain, and this blunts β-TrCP-mediated turnover of Nrf2
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