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The enzymes of the glutathione system contribute to the deactivation of H 2 O 2 and hydroperoxides, utilizing selenium as a cofactor
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+-More strikingly, the findings suggest that GPX4 plays a crucial role in preserving intestinal homeostasis by protecting against lipid peroxidation, as evidenced by the increased vulnerability of IEC Gpx4 mice to DSS-induced colonic inflammation relative to their wild-type counterparts (65)
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