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The mechanism of action has been determined that “KPV inhibits the activation of NF-kappaB and MAP kinase inflammatory signaling pathways, and reduces pro-inflammatory cytokine secretion…acts via PepT1 expressed in immune and intestinal epithelial cells…..[and] reduces the incidence of DSS- and TNBS-induced colitis indicated by a decrease in pro-inflammatory cytokine expression” (Dalmasso et al., 2008)