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141 – 143 Chauhan et al 135 showed that the expression of ETC complexes (1, 2, 3, 4, and 5) is decreased in the cerebellum as well as frontal and temporal regions of the brain in children with autism, leading to abnormal energy metabolism and increased vulnerability to oxidative stress
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In the Phase I/II KRYSTAL-1 study, Krazati plus cetuximab elicited a confirmed overall response rate of 34%, all of which were partial responses, meeting the primary endpoint, according to BMS