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IP 3 -sensitive Ca 2+ stores can be activated by G protein-coupled receptors such as Group I metabotropic glutamate receptors (mGluRs) or muscarinic acetylcholine receptors, which activates phospholipase C (PLC), which in turn cleaves phosphatidylinositol biphosphate (PIP 2 ), causing the release of diacylglycerol (DAG) and IP 3
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[DOI] [PMC free article] [PubMed] [Google Scholar] Mechler K
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