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BDNF exerts its influence by binding to the tropomyosin receptor kinase B (TrkB), which triggers multiple intracellular signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, the Ras/extracellular signal-regulated kinase (ERK) pathway, and the phospholipase C-γ (PLC-γ) pathway
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