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Elderly persons tend to have a higher adipose to muscle tissue ratio, and this is therefore one reason why the half-life of some drugs, such as diazepam, is greater in the elderly
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Heme oxygenase (HO), a major cytoprotective enzyme, functions upstream of Wnt signaling and lowers lipogenesis and adipogenesis, decreasing lipid accumulation and levels of proinflammatory cytokines [99]
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