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Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit
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Moreover, the expression of P-PI3K/PI3K, P-AKT/AKT, P-mTOR/mTOR, and P62 was significantly decreased, and the expression of RAGE, LC3II/I and NF-κ Bp65 was significantly increased
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