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The tripeptide was first isolated from human plasma by Loren Pickart in 1973 (Pickart and Thaler, Nature, 1973) and later shown to tightly bind copper with a dissociation constant in the nanomolar to low-micromolar range, meaning it holds copper effectively at physiologic concentrations

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a naturally occurring amino acid that plays a crucial role in energy production by transporting fatty acids into the mitochondria