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The main challenge, however, lies in modelling a disease as heterogeneous as PD, which can present cellular and molecular hallmarks differently between individuals, despite appearing similar among patients ( 3 Mechanisms by which cells can die under various physiological and pathological conditions 3.1 Apoptosis Apoptosis, notoriously known as a type of programmed cell death, is an energy-dependent cellular process that promotes cell death by activating endonucleases and proteases, which ultimately destroy cell molecules
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The stiffened right ventricle eventually fails to maintain adequate cardiac output, culminating in cor pulmonale
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