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To assess whether the ubiquitylated sites altered by DUB inhibition resemble those affected by aging, we compared significantly altered ubiquitylated sites in PR619-treated iNeurons with those observed in aging mouse brains 5 (Fig
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They observed a nearly 50% reduction in sputum neutrophil elastase and improvements in lung function and QoL-related domains, without increased adverse events compared to placebo [112]
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