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injected 8-month-old female rats subcutaneously for three months with methylprednisolone 9 mg/kg/day, ipamorelin 100 µg/kg three times daily, or both together (2001, Growth Hormone & IGF Research , 10.1054/ghir.2001.0239)
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It is unclear precisely how viruses regulate TCA metabolite hubs, but high-throughput metabolomic analysis reveals elevated plasma succinic acid in moderate and severe COVID-19 disease 57,69 , and administration of dimethyl itaconate (a derivative of itaconate) during influenza A virus infection in mice reduced pulmonary inflammation and improved survival 59
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